Ongoing Research
What we do
01
Mapping the Cancer-Associated Fibroblast Landscape
We explore the unique roles of spatially distinct cancer-associated fibroblasts (CAFs) in shaping the radiotherapy response of tumors.
Bouchard G, Garcia-Marques FJ, Karacosta LG, Zhang W, Bermudez A, Riley NM, Varma S, Mehl LC, Benson JA, Shrager JB, Bertozzi CR, Pitteri SJ, Giaccia AJ, Plevritis SK. Multiomics Analysis of Spatially Distinct Stromal Cells Reveals Tumor-Induced O-Glycosylation of the CDK4-pRB Axis in Fibroblasts at the Invasive Tumor Edge. Cancer Res. 2022 Feb 15;82(4):648-664. doi: 10.1158/0008-5472.CAN-21-1705. PubMed PMID: 34853070; PubMed Central PMCID: PMC9075699.
02
Exploring the Colocatome
We employ the ensemble of cell-cell colocalizations, known as the colocatome, as a spatial -omic tool to dissect the complex architecture of diseases, integrating patient-derived in vitro models with human histological specimens.
Bouchard, G., Zhang, W., Ilerten, I. et al. A quantitative spatial cell-cell colocalizations framework enabling comparisons between in vitro assembloids and pathological specimens. Nat Commun 16, 1392 (2025). https://doi.org/10.1038/s41467-024-55129-6
03
Mapping Metabolic
Niches
We explore the spatiometabolic dynamics of lung adenocarcinoma, identifying critical O-glycosylation hotspots that that fuel tumor survival against radiotherapy.